Life Science
The high performance together with the easy-to-use flow injection
system makes BI-SPR instruments the best choice for life science
applications. Examples include:
• Gene assays (e.g., single nucleotide
polymorphism) and DNA/DNA 
interactions
• Immunosensing (ligand-receptor, antibody-antigen, etc.)
• DNA/protein, protein/protein and protein/drug interactions
• Protein unfolding and conformational changes
• Drug discovery and development
Click here for the flow-injection
technique
Electrochemical SPR Measurements
Simultaneous electrochemical and SPR measurements provide additional
information and new insights into various electrochemical processes,
facilitating users to develop new electroanalytical and surface
chemistry applications. Examples include:
• Anodic stripping analysis
• Electropolymerization, electrodeposition, and corrosion
• Conformational changes of immobilized redox molecules
• Charge transfer processes
• Potential-controlled molecular adsorption processes
Click here for fundamentals
of electrochemical SPR
Chemical Vapor Sensing
The gas detection module allows users to study molecular adsorption
and desorption processes in the gas phase, and detect various
chemical vapors by functionalizing the SPR sensor chips for
various applications, such as:
• Fundamental solid-gas interface studies
• Detection of toxic molecules in the environment
• Chemical analysis of human breathes for medical research
Click here for more on chemical
vapor sensing
Other Applications
The BI-SPR system can also be applied to food safety and quality
control and environmental monitoring:
• Trace metal analysis (e.g., to Pb2+
in drinking water)
• Screening hazardous residues (e.g., amines in degraded foods)
• Analyzing nutritious ingredients
Technical Note 101
101 - Principle of SPR detection
Application Notes
101
- Fast Kinetics of Conformational Changes in Proteins
102
- Electrochemical SPR: Redox-Induced Protein Conformational
Changes
103
- Electrochemical SPR: Metal Deposition/Stripping and Reorganization
of Electroactive Organic Thin Films
104
- Flow-Injection SPR: Sensitive Determinations of Heavy Metal
Ions
105
- Protein/Drug Interaction: Ferulic Acid and Bovine Serum Albumin
106
- Flow Injection-SPR: Sensitive and Sequence-Specific DNA Assays
107
- Binding Kinetics Analysis with SPR: Interaction between Bovine Serum Albumin (BSA) and Anti-BSA
